Goldenseal can provide health benefits like: Antibacterial Eye Support Goldenseal is a common ingredient in herbal eyewashes to help with itchiness from seasonal allergies. Colds and other upper respiratory tract infections. Detoxing or passing a drug test. Goldenseal extract has been shown to provide effects that lower blood sugar levels to help prevent insulin resistance and diabetes, largely thanks to the plant’s berberine content. Berberine’s antioxidant and anti-inflammatory activities may also help to battle the development of diabetes and insulin resistance.